Protein Modification Reagents
Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 1 ML
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. This product is for research use only and not sold to patients.
- Incorporates an (S,R,S)-AHPC-based VHL ligand
- Features a 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Induces ubiquitination and subsequent proteasomal degradation of target proteins
Medchemexpress LLC Mal-amido-PEG6-acid | 1334177-79-5 | 99.3% | 100 MG
Mal-amido-PEG6-acid is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, making them suitable for research applications.
- PEG-based PROTAC linker
- Facilitates the synthesis of PROTACs
- Utilizes the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
- High purity (99.3%)
- Appears as an off-white to gray solid
Medchemexpress LLC Propargyl-PEG6-N3 | 1198080-03-3 | 25 MG
Propargyl-PEG6-N3 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions
- Engages in strain-promoted alkyne-azide cycloaddition reactions
Medchemexpress LLC DSPE-PEG2-mal | 1915739-87-5 | 99.9% | 1058.37 | C55H100N3O14P | 5 MG
DSPE-PEG2-mal is a PEG-based maleimide-functionalized linker that couples a DSPE lipid moiety to a short PEG spacer terminated with a maleimide group. It is intended for thiol-directed conjugation in the synthesis of PROTACs and other bioconjugates, providing a lipid anchor with improved solubility and membrane association. Manufacturer-reported properties include high purity, molecular weight ~1058.37, and formula C55H100N3O14P.
- Provides a maleimide terminus for thiol-specific conjugation.
- Contains a DSPE lipid moiety for membrane anchoring.
- Includes a short PEG spacer to improve solubility and reduce steric hindrance.
- High reported purity suitable for research applications.
- Solid, white to off-white appearance for convenient handling.
Medchemexpress LLC HS-PEG5-CH2CH2NH2 hydrochloride | 1446256-16-1 | 98.0% | C12H28ClNO5S | 10MG
HS-PEG5-CH2CH2NH2 hydrochloride is a thiol-terminated PEG5 linker supplied as the hydrochloride salt, intended for synthesis of PROTACs and other bioconjugates. It provides a short, flexible spacer with terminal thiol and amine groups for versatile conjugation chemistries.
- Thiol-terminated PEG5 linker for conjugation chemistries.
- Terminal ethyleneamine available as hydrochloride salt.
- Short, flexible spacer suitable for PROTAC design.
- High purity (98.0%) for consistent synthetic performance.
- Compatible with common bioconjugation reactions.
Medchemexpress LLC Cyanine 5-polyethylene glycol3-TCO | 99.2% | 845.55 | C49H69ClN4O6 | 10 MG
Cy5-PEG3-TCO is a Cy5-derived fluorescent probe bearing a three-unit polyethylene glycol (PEG3) spacer and a trans-cyclooctene (TCO) functional group. It is designed for bioorthogonal labeling via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-functionalized partners and is supplied as a solid for laboratory use.
- Cyanine 5 fluorescent core for near-infrared imaging
- PEG3 spacer improves solubility and reduces steric hindrance
- TCO group enables rapid iEDDA click chemistry with tetrazines
- High purity (99.2%) suitable for labeling applications
- Soluble in DMSO (≈16.67 mg/mL); may require ultrasonic
- Stored sealed away from moisture and light at 4°C (solid)
Medchemexpress LLC M-PEG5-azide | 1202681-04-6 | 50 MG
M-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules
Medchemexpress LLC DNP-PEG4-acid | 858126-76-8 | 100 MG
DNP-PEG4-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are compounds that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, consisting of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Relevant for cancer and cancer targeted therapy research
Medchemexpress LLC Biotin-PEG2-azide | 1910803-72-3 | 97.0% | 1 G
Biotin-PEG2-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 250 MG
DBCO-PEG4-DBCO is a versatile PEG-based PROTAC linker and a cleavable ADC linker. It is utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- Used in PROTAC synthesis
- Cleavable ADC linker
- Click chemistry reagent
- Features a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide groups
Medchemexpress LLC Tos-PEG4-THP | 86259-89-4 | 250 MG
Tos-PEG4-THP is a PEG-based PROTAC linker designed for use in the synthesis of PROTAC K-Ras Degrader-1. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins, featuring two different ligands connected by a linker: one for an E3 ubiquitin ligase and another for the target protein.
- Used in PROTAC synthesis
- Targeted for PROTAC linkers and PROTAC pathway
- Storage at -20°C, under nitrogen
- Solvent storage at -80°C for 6 months; -20°C for 1 month (under nitrogen)
- Soluble in H2O at 100 mg/mL
Medchemexpress LLC Amino-PEG5-CH2COOH | 141282-35-1 | ≥97.0% | 250 MG
Amino-PEG5-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs (proteolysis-targeting chimeras) exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They function by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Used for synthesizing PROTACs
- Facilitates selective degradation of target proteins
- Molecular weight: 295.33
- Chemical formula: C12H25NO7
- Appearance: Solid
- Color: White to off-white
TARGETMOL CHEMICALS INC DBCO-PEG4-NHS ESTER 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1]. purity: 95%
eMolecules m-PEG2-acid | Broadpharm | 149577-05-9 | MFCD09939037 | 148.158 | C6H12O4 | 98.000 | COCCOCCC(O)=O | 1g | 229582838
m-PEG2-acid | Broadpharm | 149577-05-9 | MFCD09939037 | 148.158 | C6H12O4 | 98.000 | COCCOCCC(O)=O | 1g | 229582838
eMolecules DBCO-PEG4-triethoxysilane | 2353410-02-1 | | 250mg
Broadpharm | DBCO-PEG4-triethoxysilane | 250mg | 550804542 | BP-24137 | 98.000 | 2353410-02-1 | | 755.981 | C39H57N3O10Si
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